Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
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Effects of Multiple Exposures to Pesticides on Plasma Cholinesterase Activity and p-nitrophenol Excretion in Rats

농약의 복합투여가 백서의 혈장 콜린에스테라제 활성도 및 요중 파라-니트로페놀 배설에 미치는 영향

  • Cha, Bong-Suk (Department of Preventive Medicine and Institute of Occupational Medicine, Yonei University Wonju College of Medicine) ;
  • Park, Jung-Gyun (Department of Preventive Medicine and Institute of Occupational Medicine, Yonei University Wonju College of Medicine) ;
  • Park, Jong-Ku (Department of Preventive Medicine and Institute of Occupational Medicine, Yonei University Wonju College of Medicine) ;
  • Chang, Sei-Jin (Department of Preventive Medicine and Institute of Occupational Medicine, Yonei University Wonju College of Medicine)
  • 차봉석 (연세대학교 원주의과대학 예방의학교실 및 직업의학연구소) ;
  • 박정균 (연세대학교 원주의과대학 예방의학교실 및 직업의학연구소) ;
  • 박종구 (연세대학교 원주의과대학 예방의학교실 및 직업의학연구소) ;
  • 장세진 (연세대학교 원주의과대학 예방의학교실 및 직업의학연구소)
  • Published : 1992.06.01
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Abstract

The effects of multiple exposures to pesticides on plasma cholinesterase(ChE) activities and urinary p-nitrophenol excretion were evaluated in rats. Rats were received single dose i.p. with $LD_{50}/100(mg/kg)$ of organophosphorous(OP), organophosphorous-organochroline(OP-OC), organophosphorous-carbamate(OP-CAB), organophosphorous-organoarsenate(OP-OA) pesticides for 4 consecutive days. In repeated administration of pesticides, plasma ChE activities were decreased, but urinary p-nitrophenol were increased after the first injection and then decreased gradually The recovery rates of ChE activities and p-nitrophenol excretion at 48 hours after the fourth Injection were delayed in comparision with the baseline value of 24 hours before the first injection. Statistical significances were found between OP and other groups except OP-OA group after the second injection in plasma ChE activities, but in urinary p-nitrophenol excretion there was statistical significance only between OP and OP-CAB.

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