Journal of Yeungnam Medical Science
- Volume 9 Issue 1
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- Pages.121-129
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- 1992
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- 2799-8010(eISSN)
The Effect of Regular Physical Exercise on Glucose Uptake in Soleus and Intravenous Glucose Tolerance in Streptoztocin Diabetic Rats
규칙적인 운동부하가 Streptozotocin 투여 흰쥐 골격근의 당섭취와 당내성에 미치는 영향
- Chun, Myung-Heup (Department of Physiology College of Medicine, Yeungnam University) ;
- Kim, Yong-Woon (Department of Physiology College of Medicine, Yeungnam University) ;
- Kim, Jong-Yeon (Department of Physiology College of Medicine, Yeungnam University) ;
- Lee, Young-Man (Department of Physiology College of Medicine, Yeungnam University) ;
- Lee, Suck-Kang (Department of Physiology College of Medicine, Yeungnam University)
- 전명흡 (영남대학교 의과대학 생리학교실) ;
- 김용운 (영남대학교 의과대학 생리학교실) ;
- 김종연 (영남대학교 의과대학 생리학교실) ;
- 이영만 (영남대학교 의과대학 생리학교실) ;
- 이석강 (영남대학교 의과대학 생리학교실)
- Published : 1992.06.30
Abstract
The effect of exercise on plasma insulin, free fatty acid, and glucose uptake and glycogen concentration in soleus, and intravenous glucose tolerance of streptozotocin treated, diabetic Sprague-Dawley rats were studied. Diabetic-trained animals were Subjected to a regular program of treadmill running for 4 weeks. Seventy-two hours after the last training session, basal and insulin-stimulated glucose uptake was studied in incubated strips(about 20mg) of soleus muscle in vitro. Glucose tolerance was measured with intravenous infusion of 0.5g glucose/kg body weight. In diabetic rats, training was associated with increased glucose uptake in basal and maximal insulin concentrations, decreased fasting glucose concentrations, and increased muscle glycogen levels, but there were no changes in glucose tolerance curve and plasma insulin concentrations. These results suggest that regular running program for 4 weeks improve responsiveness of insulin on soleus muscle, but fails to cause improvement of impaired intravenous glucose tolerance in mild degree streptozotocin induced diabetic rats.
STZ투여 전후 2주씩 4주간의 규칙적인 운동 부하가 당뇨흰쥐의 골격근 당섭취와 당내성에 미치는 영향을 알아보기 위하여 Sprague-Dawley종 수컷 흰쥐를 사용하여 soleus근의 당섭취를 시험관에서