Applied Microscopy
- 제22권2호
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- Pages.1-14
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- 1992
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- 2287-5123(pISSN)
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- 2287-4445(eISSN)
방사선이 흰쥐 갑상샘 소포곁세포에 미치는 영향에 대한 미세구조적 연구
Electron Microscopic Study on the Parafollicular Cells of the Thyroid Gland of the Head and Neck-Irradiated Rats
- 김용식 (순천향대학교 의과대학 해부학교실) ;
- 양남길 (순천향대학교 의과대학 해부학교실) ;
- 안의태 (순천향대학교 의과대학 해부학교실) ;
- 고정식 (순천향대학교 의과대학 해부학교실) ;
-
박경호
(순천향대학교 의과대학 해부학교실) ;
- 김진국 (순천향대학교 의과대학 해부학교실)
- Kim, Young-Sik (Department of Anatomy, College of Medicine, Soonchunhyang University) ;
- Yang, Nam-Gil (Department of Anatomy, College of Medicine, Soonchunhyang University) ;
- Ahn, E-Tay (Department of Anatomy, College of Medicine, Soonchunhyang University) ;
- Ko, Jeong-Sik (Department of Anatomy, College of Medicine, Soonchunhyang University) ;
-
Park, Kyung-Ho
(Department of Anatomy, College of Medicine, Soonchunhyang University) ;
- Kim, Jin-Gook (Department of Anatomy, College of Medicine, Soonchunhyang University)
- 발행 : 1992.12.01
초록
This experiment was performed to study the morphological responses of the parafollicular cells of rat following X-ray irradiation. Male rats were divided into normal and experimental groups. The head and neck region of the rat, under sodium thiopental anesthesia, was exposed to 3,000 rads or 6,000 rads of radiation in a single dose, respectively. The source was a Mitsubishi Linear Accelerator ML-4MV. The target to skin distance was 80 cm, and the dose rate was 200 rads/min. The rate of experimental groups were sacrificed on the 6th hour, 2nd and 6th day after X-ray irradiation. Pieces of the tissue taken from the thyroid gland were fixed in 2.5% glutaraldehyde-1.5% paraformaldehyde (0.1M Millonig's phosphate buffer, pH 7.3), and in 1% osmium tetroxide (0.1M Millonig's phosphate buffer, pH 7.3), and embedded in araldite mixture. The ultrathin sections stained with uranyl acetate and lead citrate were observed with JEM 100 CX-II electron microscope. The results were as follow; 1. Two types of the parafollicular cells, according to their electron densities, were found, i. e., light cells and dark cells. 2. Three types of the parafollicular cells, according to their sizes of secretory granules were found, i.e., small granule cells (
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