Study on Adhesion Formation by Artificial Injuries in Rats

쥐에서 인공창상에 의한 유착형성에 관한 연구

This experiment was carried out to establish the grade of adhesion formation and changes of blood following artificial injuries such as abrasion, incision and electrocautery on colon and uterine horns in rats. 36 rats (abrasion-, incision-, electrocautery-treated groups) had laparotomy and abdominal injuries, twelve rats( control group) had only laparotomy, Ten days fellowing abdominal injuries, the score of adhesion formation and changes of blood were noted 1. Electrocautery-treated group was significant evident in adhesion formation in colon(p<0.01) and electrocautery and incision-treated groups were more evident than abrasion and control group in uterine horns(p<0.01) 2. Changes of erythrocytes number and PCV were tended to decrease during 5 days after operation, but recover normal level 10 days after operation. 3. Changes of leucocytes number were showed to significantly increase in electrocautery and incision-treated groups 5 days after operation. 4. The electrocautery-treated group was showed to significantly decrease in plasma protein and increase in plasma fibrinogen concentration.