The Korean Journal of Nuclear Medicine (대한핵의학회지)

The Korean Society of Nuclear Medicine (대한핵의학회)
권호 표지

Estimation of Glomerular Filtration Rate Using $^{99m}Tc-DTPA$ and Gamma Scintillation Camera

$^{99m}Tc-DTPA$ 및 Gamma Scintillation Camera를 이용한 사구체 여과율의 측정

  • Choe, Jae-Gol (Department of Radiology, College of Medicine, Korea University) ;
  • Baik, Sei-Hyun (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Lee, Min-Jae (Department of Radiology, College of Medicine, Korea University) ;
  • Suh, Won-Hyuck (Department of Radiology, College of Medicine, Korea University)
  • 최재걸 (고려대학교 의과대학 방사선과학교실) ;
  • 백세현 (고려대학교 의과대학 내과학교실) ;
  • 이민재 (고려대학교 의과대학 방사선과학교실) ;
  • 서원혁 (고려대학교 의과대학 방사선과학교실)
  • Published : 1992.05.31
Download PDF
⟨ Previous Next ⟩

Abstract

The radioisotopic measurement of glomerular filtration rate (GFR) has required analysis of serial blood or urine samples over several hours, and does not allow measurement of separate renal function unless separate catherterization of individual ureters is done. Gates described isotopic method for the measurement of global and unilateral GFR based on the determination by scintillation camera of the fraction of the injected dose of $^{99m}Tc-diethylenetriaminepentaacetic$ acid (DTPA) present in the kidneys 2-3 minutes after its administration. We calculated GFR according to Gates' method in 58 adult patients with various levels of global renal function using $^{99m}Tc$ DTPA and validated this technique by correlation with 24 hour creatinine clearance. A good correlation was observed between 24 hour creatinine clearance and GFR calculated by Gates' formula, with an r value of 0.91 (p<0.01). We concluded that determination of GFR according to the Gates' formula allows good and reproducible prediction of GFR with great rapidity and simplicity rendering this technique suitable for clinical practice.

Keywords