Journal of the Korean Chemical Society (대한화학회지)

Korean Chemical Society (대한화학회)
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Synthesis of Novel 1,2,4-Triazole Derivative

새로운 1,2,4-Triazole 유도체의 합성에 관한 연구

  • Kim, Ho Sik (Department of Chemistry, Teacher's College, Hyosung Women's University) ;
  • Park Tae Joo (Department of Chemistry, Teacher's College, Hyosung Women's University) ;
  • Doh Yi Hyang (Department of Chemistry, Teacher's College, Hyosung Women's University) ;
  • Lee Man Kil (Department of Chemistry, Koshin University) ;
  • Kurasawa Yoshihisa (School of Pharmaceutical Sciences, Kitasato University)
  • 김호식 (曉星女子大學校 師範大學 化學科) ;
  • 박태주 (曉星女子大學校 師範大學 化學科) ;
  • 도이향 (曉星女子大學校 師範大學 化學科) ;
  • 이만길 (高神大學 化學科) ;
  • 창택가구 (日本 北理大學 藥學部)
  • Published : 1992.10.20
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Abstract

${\alpha}-Arylhydrazonoacylazide(7) was synthesized starting from {\circo}-phenylenediamine(3) in four steps. The tautomeric behavior of {\alpha}-arylhydrazonoacylazide(7) between the hydrazone imine and diazenyl enamine forms in the dimethyl sulfoxide solution was investigated on the basis of the tautomer ratio determined by the ^1H-NMR spectral data. The 1-aryl-3-quinoxalinyl-1,2,4-triazol(8) was synthesized from {\alpha}-arylhydrazonoacylazide(7) by refluxing in benzene.$

${\circo}-페닐렌디아민(3)을 출발물질로 하여 4단계를 거쳐 {\alpha}-arylhydrazonoacylazide(7)를 합성하였다. 얻어진 {\alpha}-arylhydrazonoacylazide(7)는 디메틸슬폭시드 용액에서 hydrazone imine형과 diazenyl enamine형으로 존재하는데 이들 사이의 토오토메리 현상을 ^1H-NMR 스펙트럼 데이타에 의하여 측정된 토오토머 비로서 고찰하였다. {\alpha}-arylhydrazonoacylazide(7)를 벤젠용매에서 환류시켜 1-aryl-3-quinoxalinyl-1,2,4-triazol(8)을 합성하였다.$

Keywords

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