Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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The Application of NMR Techniques to the Structural Confirmation of O-Substituted 3,4-Dihydroxyphenylacetic Acid Derivatives

  • Published : 1992.02.20
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Abstract

The structures of the compounds, 1, 2, 3, and 4, which were precursors of analgesics, were confirmed by modern NMR techniques. The complete $^{13}C-NMR$ assignments of these systems were established by applying COLOC (COrrelated spectroscopy for LOng range Couplings), HETCOR (HETeronuclear CORrelated spectroscopy), RCT (Relay Coherence Transfer), and NOE difference spectroscopy. The limitation of COLOC approach which has been widely used recently is discussed.

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