Screening for Antitumor Efficacy from the Wild Plants in Korea

한국산 천연항종양성 자원의 Screening에 대하여

  • Published : 1992.11.01

Abstract

This experiment was Conducted ta screening for the anti-cancer efficacy from the wild plants which are naturally growing in the Korea. The results are as follows. The results were shown thatZea may L. nad significantly effects on mediculal efficacy anganist anti-tumor by usulg the totalpacked cell volume methods and also, severals plants, such as Sofonum nigrum, Patrinia hispidoBunge, Eragrostis, ferrugenia Beauv, Salaginela pouzolgiana Spring, Platrycarya strobilacea Bunge,Codonopsis lanceolata Benth. et Hook fil. which are collected from Giri and Mooju mountain in Koreaand Nagano in Japan were showed effects on auti-tumor. But the pharmaceologial activities ofPharbitis nil Choisy was believed to strong effec on anti - cancer tumors, while toxicity of its wasshown high that induced te kill all used mice. Extraction of Patrinia hispida Bunge, Pharbitis nilChoisy, Toilis japonica DC, Eragrostis erruginea Beauv. and Forsythia koreana Nakai showed effec-tively supressed on growth rate of cancer tumor by the below 50 percent of T/C ratio at 30mg /mlof extraction from plant. That Is strong activity while Reynouxria japonica Houtt. was observed onlymild activities. The above results many possibly suggest that Patrinia hispido Bunge and Eragrostisferrugina Beauv. inhibited the growth of cancer tumor by the both total packed cell volume methodand cytotoxicity method. Although basic research is still going on, we will find out an accurate moth-od for developing useful medicinal plant to improve pharmacological activites against anti-cancertumor, especialy, in Eragrostis ferruginea Beauv.

Keywords

References

  1. J. Nat. Prod. v.45 M.Suffness;J.Douros
  2. Lloidia v.40 G.A.Cordell;N.R.Farnsworth
  3. Anticancer agents based on natural product methods J.M.Casady;J.D.Douros
  4. Eight Symposium by Kanto Branch of Pharmaceutical Society of Japan Chemistry and biological activity of antineoplastic natural products H.Itokawa
  5. Chem. Pharm. Bull. v.33 H.Itokawa;F.Hirayama;K.Funakoshi;K.Takeya
  6. Chem. Pharm. Bull. v.35 H.Itokawa;S.Tsuruoka;K.Takeya
  7. Japan. J. Pharmacog. v.33 H.Itokawa;K.Wanatabe;S.Mihashi
  8. Japan. J. Pharmacog. v.36 H.Itokawa;K.Watanabe;K.Mihara;K.Takeya
  9. 29th Kanto Branch Symposium of Pharmaceutical Society of Japan A.Hoshi
  10. Chem. Pharm. Bull. v.31 H.Itokawa;K.Mihara;K.Takeya
  11. Chem. Pharm. Bull. v.31 H.Itokawa;K.Takeya;K.Mihara;N.Mori;T.Hamanaka;T.Sonobe;Y.Iitaka
  12. Chem. Pharm. Bull. v.32 H.Itokawa;K.Takeya;N.Mori;T.Hamanaka;T.Sonobe;K.Mihara
  13. Chem. Pharm. Bull. v.32 H.Itokawa;K.Takeya;N.More;T.Sonobe;N.Serisawa;T.Hamanaka;S.Mihara
  14. Planta Medica v.51 H.Itokawa;K.Takeya;N.Mori;S.Kidokoro;H.Yamamoto
  15. Gann v.75 H.Itokawa;K.Takeya;N.Mori;M.Takanashi;H.Yamamoto;T.Sonobe;S.Kidokoro
  16. 14th International Congress of Chemotherapy H.Itokawa;K.Takeya;T.Hamanaka;M.Yakanashi;N.Mori;S.Tsukagoshi
  17. J. Amer. Chem. Soc. v.99 S.D.Jolad;J.R.Cole
  18. J. Amer. Chem. Soc. v.105 R.B.Bates;J.R.Cole
  19. Chem. Pharm. Bull. v.34 H.Itokawa;K.Takeya;N.Mori;T.Sonobe;S.Mihashi;T.Hamanaka
  20. 東洋資源植物學會誌 v.4 no.1 Eragrostis ferruginea의 抗腫瘍性 Screening Test S.C.Shin;J.I.Lee;S.R.Lee;E.S.Yoon
  21. 東洋資源植物學會誌 v.4 no.2 Eragrostis ferruginea에서 추출된 Diterpenoids S.R.Lee;E.S.Yoon;S.C.Shin;J.I.Lee
  22. 東洋資源植物學會誌 v.5 no.1 韓國産 개나리 Forsythia viridissima의 細胞毒性 成分에 關한 硏究 H.Itokawa;K.Matsumoto;H.Morita;K.Takeya;S.R.Lee
  23. J. Pharmacobio v.8 H.Itokawa;K.Takeya;N.Mori;T.sonobe;K.Mihara;M.Takanashi;H.Yamamoto