Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effects of Ursolic Acid Isolated from Eriobotrya Japonica on c-myc and c-Ha-ras Oncogene Expression at Sarcoma 180 cell

Sarcoma 180 세포에서 비파엽에서 분리한 올솔레산이 c-myc 과 c-Ha-ras 암유전자 발현에 미치는 영향

  • Yang-Ae Choi (Department of Biology, Food Science Pusan National University) ;
  • Tae Hyong Rhew (Department of Biology, Food Science Pusan National University) ;
  • Kun-Young Park (Departments of Biology , Food Science Nutrition , Pusan National University) ;
  • Hae-Young Chung (Department of Biology , Food Science and Pharmacy, Pusan National University) ;
  • Jae-Chung Hah (Department of Biology, Food Science Pusan National University)
  • Published : 1992.06.01
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Abstract

The sarcoma 180 cells were treated with ursolic acid which was previously extracted from leaves of Eriobotrya japonica Lindy (Rosaceae) and identified as a potent anticarinogenic agent. Suppressing effects of the compounds with testing changes in selected oncogenes expression were examined by using the northern hybridization method. Ursolic acid significantly suppressed c-myc oncogene expression. However, c-ha-ras oncogene expression was lowered slightly with the ursolic acid treatment. Therefore, it was concluded that preproven anticarcinogenic effects of ursolic acid should be partly ascribed to the modified oncogenic expression.

비파엽에서 분리동정한 활성성분인 울솔레산을 sarcoma 180 cells에 처리하여 c-myc과 c-Ha-ras 암유전자 발현에 있어서 변화를 조사하였다. 그 결과 c-myc 유전자의 발현에서는 뚜렸한 감소가 관찰되었으나 c-Ha-ras 유전자 발현은 대조군과 거의 차이가 없었다. Cell proliferation에 중요한 역할을 하는 것으로 추측되고 있는 c-myc 유전자 발현의 감소는 지금까지 보고된 그 물질의 antipromotional effect와 관계있는 것으로 보여진다.

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