Toxicological Research

  • 제8권1호
  • /
  • Pages.49-61
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  • 1992
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  • 1976-8257(pISSN)
  • /
  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

4-WEEK SUBCUTANEOUS TOXICITY STUDY OF RECOMBINANT GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR (LBD-005) IN RATS

  • Kim, Hyoung-Chin (Toxicology Research Center Korea Research Institute of Chemical Technology) ;
  • Boohyon Kang (Toxicology Research Center Korea Research Institute of Chemical Technology) ;
  • Han, Sang-Seop (Toxicology Research Center Korea Research Institute of Chemical Technology) ;
  • Park, Jung-Koo (Toxicology Research Center Korea Research Institute of Chemical Technology)
  • 발행 : 1992.06.01
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초록

Recombinant granulocyte-macrophage colony stimulating factor was subcutaneously administered to both sexes of Sprague-Dawley rats at the doses of 0, 0.5, 1 and 2mg/kg of body weight five days per week for 4 weeks to evaluate the subchronic toxicity. There were decreased 1 and 2 mg/kg. In the serum, changes were decreased alkaline phostatase(ALP) in the female groups dosed at 1 and 2mg/kg, and increased glutamic oxaloacetic transaminiase (GOT)in the male groups dosed at 0.5 and 2.0mg/kg.

키워드

참고문헌

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