Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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The Role of Substituents of ar-Turmerone for its Anticancer Activity

  • Oh, Won-Geun (College of Pharmacy, Chung-Nam National University) ;
  • Baik, Kyong-Up (College of Pharmacy, Chung-Nam National University) ;
  • Jung, Sang-Hun (College of Pharmacy, Chung-Nam National University) ;
  • Ahn, Byung-Zun (College of Pharmacy, Chung-Nam National University)
  • Published : 1992.09.01
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Abstract

For the evaluation of the role of substituents of ar-turmerone for its anticancer activity, ar-turmerone (1a) and its analogs like 2-methyl-6-(4'-methyphenyl)-2-octen-4-one (1b), 2-methyl-6-phenyl-2-hepten-4-one (1c), 2-methyl-6-phenyl-2-octen-4-one (1d) and 2 methyl-6-(trans-4'-methylcyclohexyl)-2-hepten-4-one (1e) were preparedd and their cytotoxic activities against $L_{1210}$ cell were determined. Omission of methyl group at para-position dose not variate the cytotoxicity of ar-turmerone. Elongation of alkyl group at 6-position decreases $ED_{50}$ value. Saturation of aromatic ring of ar-turmerone markedly decreases the cytotoxicity. Therefore the smaller size of alkyl group at 6-position and aromatic ring of ar-turmerone should be essential for exhibiting its anticancer activity.

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