Archives of Pharmacal Research
- Volume 15 Issue 2
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- Pages.187-189
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- 1992
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthetic $\beta$ -Lactam Antibiotics VI. Antibacterial Activity of Some 7$\beta$ [-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3-(pyrrolidinium) methylcephalosporins
- Lim, Dong-Yeol (Organic Chemistry Lab 2, Korea Institute of Science and Technology) ;
- Kim, Kyung-Bo (Organic Chemistry Lab 2, Korea Institute of Science and Technology) ;
- Yang, Woon-Yang (Organic Chemistry Lab 2, Korea Institute of Science and Technology) ;
- Park, Sang-Woo (Organic Chemistry Lab 2, Korea Institute of Science and Technology) ;
- Kim, You-Seung (Organic Chemistry Lab 2, Korea Institute of Science and Technology)
- Published : 1992.06.01
Abstract
In the preceding paper, we reported the synthessis and biological properties of cephalosporins having quinoliniumthiomethyls at the C-3 position and demonstrated that quinoliniumthiomethylcephalosporins exhibited an extended antibacterial spectrum including antipseudomonal activity, especially strong antiGram-positive activity. With the aim of elaboration to optimize the antibacterial potency of the quaternary ammonium cephalosporins, we have studied the modification of substituents in the pyrrolidine ring of cefepime 1 which is characterized by its potent activity.
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