Inhibitory Effect of Papaverine on the Contraction Induced by Transmural Stimulation in the Isolated Mouse Vas Deferens

  • Published : 1992.06.01

Abstract

The effect of papaverine on the contractions induced by adrenergic neurotransmission in the isolated mouse vas deferens was investigated. Papaverine, $10^{-7}-10^{-5}$M, showed a dose-dependent and reversible inhibition on the induced contractions. When the frequency of stimulation was varied (2.5-20.0 Hz), the inhibitory effect tended to be marked at the lower frequencies.

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