Journal of Ginseng Research
- 제16권2호
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- Pages.93-98
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- 1992
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- 1226-8453(pISSN)
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- 2093-4947(eISSN)
펜타조신의 진통작용 및 내성형성에 미치는 인삼 사포닌의 효과
Effects of Ginseng Total Saponins on the Analgesia and Tolerance Development of Pentazocine
- Kim, Hack-Seang (Department of Pharmacology, College of Pharmacy, Chungbuk National University) ;
- Ann, Sun-Hee (Department of Pharmacology, College of Pharmacy, Chungbuk National University) ;
- Seong, Yeon-Hee (Department of Veterinary Pharmacology, College of Agriculture, Chungbuk National University) ;
- Kim, Sun-Hye (Department of Pharmacology, College of Pharmacy, Chungbuk National University) ;
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Oh, Ki-Wan
(Department of Pharmacology, College of Pharmacy, Chungbuk National University)
- 발행 : 1992.08.01
초록
This study examined the Influence of ginseng total saponins (GTS) on the analgestic action and tolerance development of pentazocine in mice. Pentazocine prolonged the latency to response in the tail flick rather than in the tail pinch test. The analgesic effect of pentaEocine was antagonized by naloxone and completely eliminated by pretreatment u·ith f-chlorophenylalanine (PCPA). GTS provented the pentasocine-incuced analgesia ann inhibited the development of tolerance to pentazocine. The antagonistic effect of GTS on the pentazocine-induced analgesia was abolished by 5-HTP, but not by L-DOPA. These results suggest that GTS inhibits the analgesic action of pentazocine by the interaction with serotonergic neuron.