Korean Journal of Clinical Pharmacy (한국임상약학회지)
- Volume 2 Issue 1
- /
- Pages.1-9
- /
- 1992
- /
- 1226-6051(pISSN)
- /
- 2508-786X(eISSN)
Protective Effect of Urokinase on Reperfusion Function in Isolated Perfused Rat Heart, and Anti-platelet Aggregation Effect Invitro and Exvivo
Urokinase의 적출심장의 심근허혈에 대한 보호작용과 invitro 및 exvivo항혈전작용 실험
-
Kwon, Kwangil
(College of Pharmacy, Chung Nam National University)
;
- Shin, Hongseup (College of Pharmacy, Chung Nam National University) ;
- Yoon, Jongok (College of Pharmacy, Chung Nam National University) ;
- Kim, Boshin (College of Pharmacy, Chung Nam National University) ;
- Min, Jiha (College of Pharmacy, Chung Nam National University) ;
-
Lee, Byungho
(Korea Research Institute of Chemical Technology)
;
- Huh, Inhoe (College of Pharmacy, Jung Ang University)
-
권광일
(충남대학교 약학대학)
;
- 신흥섭 (충남대학교 약학대학) ;
- 윤정옥 (충남대학교 약학대학) ;
- 김보신 (충남대학교 약학대학) ;
- 민지하 (충남대학교 약학대학) ;
-
이병호
(한국화학연구소)
;
- 허인회 (중앙대학교 약학대학)
- Published : 1992.05.01
Abstract
Protective effect of urokinase on reperfusion were studied followed by global ischemia in the isolated perfused rat heart. Separately, anti-platelet aggregation effect of urokinase also investigated. Urokinase exhibited positive effect for the protection of rat heart function by increasing the LV dp/dt, coronary flow(CF) and the Tate pressure product(RPP), and by decreasing the LVEDP on reperfusion. Urokinase also decreased arrhythmia by
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