Synthesis and antifungal activity of N-substituted-5-chloro-1,3-dimethylpyra-zole-4-carboxamide

N-치환-5-chloro-1,3-dimethylpyrazole-4-carboxamide의 합성과 살균력

Twenty-six N-substituted-5-chloro-1,3-dimethylpyrazole-4-carboxamide were synthesized and their antifungal activity against Rhizoctonia solani, Pyricularia oryzae, Botrytis cinerea and Colletotricum gleosporiodes was compared. N-phenyl-5-chloro-l,3-dimethylpyrazole-4-carboxamides having electron releasing group at the meta position of phenyl ring demonstrated good fugicidal activity against R. solani.

생리활성을 갖는 신규물질탐색의 일환으로 26종의 N-치환-5-chloro-1,3-dimethylpyra-zole-4-carboxamide 화합물을 합성하고, 이들 구조를 $^1H-NMR$로 확인하였다. 이들 유도체들을 Rhizoctonia solani, Botrytis cinerea, Pyricularia oryzae 및 Colletotricum gleosporiodes에 대한 in vitro에서의 균사생육억제효과를 검정한 결과 electron releasing group으로 meta 치환된 aniline의 carboxamide가 R. solani에 대해 12.5 ppm 수준에서 70% 이상의 살균효과를 보여주었다.