Journal of Pharmaceutical Investigation
- 제22권4호
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- Pages.301-306
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- 1992
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
랫트에 있어서 딜티아젬의 대사동태에 미치는 페노바르비탈의 효과
Effect of Phenobarbital on the Metabolite Kinetics of Diltiazem in Rats
- Lee, Yong-Bok (College of Pharmacy, Chonnam National University) ;
- Koh, Ik-Bae (College of Pharmacy, Chonnam National University) ;
- Shim, Chang-Koo (College of Pharmacy, Seoul National University) ;
- Kim, Shin-Keun (College of Pharmacy, Seoul National University) ;
- Lee, Min-Hwa (College of Pharmacy, Seoul National University)
- 발행 : 1992.12.20
초록
The influence of phenobarbital (PB) pretreatment (75 mg/kg/day, i.p. for 4 days) on the metabolite kinetics of diltiazem (DTZ) was studied in rats in order to elucidate the effect of esterase induced by PB on the formation of DTZ to desacetyldiltiazem (DAD), DAD was injected via portal vein (3 mg/kg) to the control and PB-pretreated rats, The intrinsic hepatic clearance of DAD was significantly increased by PB pretreatment and the absolute bioavailability of DAD was significantly decreased in the PB-pretreated rats. According to the hepatic biotransformation model of DTZ, the fraction of systemic clearance of DTZ which forms DAD
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