Journal of Pharmaceutical Investigation
- 제22권3호
- /
- Pages.219-227
- /
- 1992
- /
- 2093-5552(pISSN)
- /
- 2093-6214(eISSN)
랫트에 있어서 페노바르비탈 전처리가 딜티아젬의 생체내 동태에 미치는 영향
The Effect of Phenobarbital Pretreatment on the Pharmacokinetics of Diltiazem in Rats
- Lee, Yong-Bok (College of Pharmacy, Chonnam National University) ;
- Koh, Ik-Bae (College of Pharmacy, Chonnam National University) ;
- Lee, Min-Hwa (College of Pharmacy, Seoul National University)
- 발행 : 1992.09.20
초록
The influence of phenobarbital (PB) pretreatment (75 mg/kg/day, i.p. for 4 days) on the pharmacokinetics of diltiazem (DTZ) and its metabolite, desacetyldiltiazem (DAD), was investigated in rats. DTZ was injected via femoral (3 mg/kg) or portal (10 mg/kg) vein to the control and PB-pretreated rats. DAD was also injected separately via femoral (3 mg/kg) vein to both groups of rats. The intrinsic hepatic plasma clearance of DTZ was found to be significantly increased (6.8-fold) by the PB pretreatment. However, the fraction of an intravenous DTZ dose converted to DAD
키워드