Journal of Pharmaceutical Investigation
- 제22권3호
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- Pages.205-210
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- 1992
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
피막법에 의한 경구투여용 제어방출제제의 개발-III-테오필린함유 제어방출제제의 제조 및 사람의 타액중 농도로부터의 평가-
Development of Controlled Release Oral Drug Delivery System by Membrane-Coating Method-III- Preparation of Theophylline Tablets and Pharmacokinetic Evaluation in Man-
- Shim, Chang-Koo (College of Pharmacy, Seoul National University) ;
- Kim, Chong-Kook (College of Pharmacy, Seoul National University) ;
- Lee, Min-Hwa (College of Pharmacy, Seoul National University) ;
- Kim, Shin-Keun (College of Pharmacy, Seoul National University)
- 발행 : 1992.09.20
초록
In order to develop a controlled-release oral drug delivery system (DDS) of theophylline (TP), microporous membrane-coated tablets were prepared and evaluated in vitro and in vivo. Rapidly water-soluble core tablets of TP (300 mg) were prepared by wet granulation and compression technique, Then the core tablets were spray-coated with polyvinylchloride (PVC) in which micronized sucrose particles were dispersed. Effect of formula compositions of coating suspensions on the pharmaceutical characteristics such as membrane strength and dissolution was investigated in vitro. The membranes remained unbroken in pH 1.2 buffer at
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