Journal of Pharmaceutical Investigation
- 제22권3호
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- Pages.185-196
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- 1992
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
5-Fluorouracil의 Prodrug에 대한 안정성 및 생체이용율에 관한 연구(I). 1-Glycyloxymethyl-5-fluorouracil HCl의 제조, 물리화학적 성질, 안정성 및 항암효과
Stability and Bioavailability on Prodrug of 5-Flurouracil (I). Synthesis, Physicochemical Properties, Stabilities and Antitumor Activities of 1-Glycyloxymethyl-5-fluorouracil Hydrochloride
- Jee, Ung-Kil (College of Pharmacy, Chungnam National University) ;
- Lee, Gye-Won (College of Pharmacy, Chungnam National University) ;
- Park, Mork-Soon (College of Pharmacy, Chungnam National University)
- 발행 : 1992.09.20
초록
To assess its suitability as a prodrug of 5-fluorouracil (5-FU), 1-glycyloxymethyl-5-FU HCl (GFU), a 5-fluorouracil derivative having a glycyloxymethyl group at the N-l position was synthetized. Its physicochemical properties and hydrolysis kinetics, in aqueous solution of pH
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