Journal of Pharmaceutical Investigation
- Volume 22 Issue 1
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- Pages.63-68
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- 1992
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Quantitation of Flurbiprofen in Isopropyl Myristate by High Performance Liquid Chromatography
고속액체크로마토그래피를 이용한 미리스틴산이소프로필증 플루르비프로펜의 정량
- Kim, Hyun (College of Pharmacy, Sung Kyun Kwan University) ;
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Chi, Sang-Cheol
(College of Pharmacy, Sung Kyun Kwan University)
- Published : 1992.03.20
Abstract
An HPLC procedure with UV detection has been developed for the quantitation of flurbiprofen released into isopropyl myristate used as the receptor phase in an in vitro membraneless drug diffusion cell. The drug and the internal standard (oxaprozin) were extracted from isopropyl myristate with a mixture of dimethylsulfoxide:methanol:water (2:1:1) and quantitated using a reverse phase