Journal of Pharmaceutical Investigation
- Volume 22 Issue 1
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- Pages.11-21
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- 1992
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Kinetic Analysis of the Hepatic Transport of Organic Anions: Role of Intracellular Cytoskeleton
유기 음이온계 약물의 간내 이행과정에 있어서 Cytoskeleton의 역할에 관한 속도론적 연구
- Chung, Youn-Bok (College of Pharmacy, Chungbuk National University) ;
- Han, Kun (College of Pharmacy, Chungbuk National University) ;
- Yuk, Dong-Yeon (College of Pharmacy, Chungbuk National University)
- Published : 1992.03.20
Abstract
The effects of colchicine on the plasma elimination and biliary excretion of various organic anions in rats were examined. Elimination of indocyanine green (ICG) or rose bengal (RB) from plasma was significantly delayed when rats were treated with colchicine (3 mg/kg body weight) 3 hr prior to the administration of the dye. On the other hand, disappearance of sulfobromophthalein (BSP) or bromophenol blue (BPB) from plasma was not influenced by colchicine. The plasma disappearance and biliary excretion of organic anions were kinetically analyzed based on a compartment model, in which the deep compartment and the unknown disposition are incorporated. The transfer rate constants of ICG or RB,
Keywords
- Organic anions;
- biliary excretion;
- indocyanine green;
- rose bengal;
- colchicine;
- sulfobromophthalein;
- bromophenol blue;
- cytoskeleton;
- hepatocyte