Korean Journal of Pharmacognosy (생약학회지)
- Volume 23 Issue 2
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- Pages.81-88
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- 1992
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
The Effect of Scoparone on the Hepatic Bromobenzene Metabolizing Enzyme System in Rats
간의 Bromobenzene 대사계에 미치는 Scoparone의 효과(I)
- Kim, Eun-Ju (College of Pharmacy, Kyungsung University) ;
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Lee, Chung-Kyu
(College of Pharmacy, Kyungsung University) ;
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Choi, Jong-Won
(College of Pharmacy, Kyungsung University)
- Published : 1992.06.30
Abstract
The effects of scoparone, one of coumarin derivative on the hepatic bromobenzene metabolizing enzyme system was estimated in rats. Scoparone pretreatment revealed dose-dependently the recovery of decrease in epoxide hydrolase activity due to the bromobenzene(310 mg/kg, i.p.) treatment. And also scoparone and scopoletin (each 5mg/kg, p.o.) pretreatments showed two times increase in the
Keywords
- scoparone;
- scopoletin;
- bromobenzene;
- mixed function oxidase;
- glutathione S-transferase;
- epoxide hydrolase