한국균학회지 (The Korean Journal of Mycology)
- 제20권4호
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- Pages.347-353
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- 1992
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- 0253-651X(pISSN)
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- 2383-5249(eISSN)
$CCl_4$ 로 독성을 유발시킨 초대배양 간세포를 이용한 고등균류로부터 간세포 보호물질의 검색
Screening of Hepatoprotective Substances from Higher Fungi by Primary Cultured Rat Hepatocytes intoxicated with Carbon Tetrachloride
- Lee, June-Woo (Biotechnology Lab., Il Yang Pharmaceutical Co., Ltd.) ;
- Han, Man-Deuk (Biotechnology Lab., Il Yang Pharmaceutical Co., Ltd.) ;
- Lee, Kweon-Haeng (Biotechnology Lab., Il Yang Pharmaceutical Co., Ltd.)
- 발행 : 1992.12.30
초록
국내에서 자생하고 있는 75균주의 고등균류를 액체배양하여 얻은 다당류를
Hepatoprotective effects of polysaccharides extracted from liquid cultured mycelia were screened by measuring the glutamic pyruvate transaminase activity of the primary cultured rat hepatocytes intoxicated with carbon tetrachloride. Sixty among 75 isolates of higher fungi showed to be hepatoprotective effect, and these were 13 of Ganoderma lucidum, 5 of Lentinus edodes, 1 of Pleurotus ostereatus, 4 of Coriolus versicolor, 2 of Lyophyllum spp., 7 of Grifora frondosa, 3 of Agaricus spp., 14 of Schizophyllum commune and 11 of Cordyceps spp.. Especially, 10 isolates, Ganoderma lucidum IY003 and IY009, Lentinus edodes IY103, Lyophyllum sp. IY402, Agaricus sp. IY701 and IY703, Schizophyllum commune IY804, IY810 and IY818, Cordyceps sp. IY902, were indicated below 80% of glutamic pyruvate transaminase activity.
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