YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Synthesis of N-(disubstituted styryl) Carboxamides

N-(2치환스티릴) 카르복사미드류의 합성

  • Kim, Soon-Ok (Department of Chemistry, Sungshin Women's University) ;
  • Hong, Sa-Mi (Department of Chemistry, Sungshin Women's University) ;
  • Lee, Seon-Hwa (Department of Chemistry, Sungshin Women's University)
  • 김순옥 (성신여자대학교 자연과학대학 화학과) ;
  • 홍사미 (성신여자대학교 자연과학대학 화학과) ;
  • 이선화 (성신여자대학교 자연과학대학 화학과)
  • Published : 1992.10.29
Download PDF
⟨ Previous Next ⟩

Abstract

For the synthesis of tuberin derivatives, N-(disubstituted styryl) carboxamides, the series of cinnamic acids were transformed through chlorides, azides to isocyanates. And then isocyanates were reduced separately by Dibal and Grignard reagent. As a result of antimicrobial susceptibility test, N-(3,4-dichlorostyryl) formamide and N-(3,4-dichlorostyrl) acetamide showed comparatively large activity against some bacteria that is, MIC was respectively 50 ppm, $6.25{\sim}50\;ppm$. MIC of other derivatives was similiar to that of tuberin, about 100.

Keywords