The Korean Journal of Nuclear Medicine (대한핵의학회지)

The Korean Society of Nuclear Medicine (대한핵의학회)
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A Study on Evaluation of Isolated Rabbit Kidney Function with Computed $^{99m}Tc-DTPA$ Scintigraphy

$^{99m}Tc-DTPA$ Scintigraphy에 의한 분리보존가토신의 기능평가에 관한 연구

  • Chung, Sun-Il (Department of Internal Medicine, College of Medicine, Gyeongsang National University) ;
  • Ha, Woo-Song (Department of General Surgery, College of Medicine, Gyeongsang National University)
  • 정순일 (경상대학교 의과대학 내과학교실) ;
  • 하우송 (경상대학교 의과대학 일반외과학교실)
  • Published : 1991.05.31
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Abstract

Computerized scintigraphv using $^{99m}Tc-DTPA$ was performed to 37 isolated rabbit kidneys after preservation for 48 hours in perfusates differing in their compositions, i. e., Group 1 (N 9) in Collins' solution, Group 2 (N 10) in Collins' plus trifluoperazine, Group 3 (N 9) in Collins' plus urokinase and Group 4 (N 9) in Collins pius urokinase plus verapamil. Satisfactory images, and statistically analyzable quantitative indices such as perfusion score, filtration rate and cortical uptake ratio (CUR) were obtained by the evaluations of first-pass perfusion, equilibration slopes and postequilibration images. Significant improvements in CUR were observed by adding trifluoperazine (Group 2) and urokinase (group 3) as compared to Collins' only group (Group 1), p<0.05 for each, and all of the three indices (perfusion score, filtration rate and CUR) were also significantly (p=0.0092 p<0.05 and p<0.05) improved by adding urokinase plus verapamil (Group 4). We concluded that the computerized scintigraphy with Tc-99m DTPA provide valuable quantitative indices for evaluation of preserved kidney funcitions and suggest its possible clinical applicability in cadaver kidney transplantation considering the safety and easiness of the prodedure.

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