Bulletin of the Korean Chemical Society

  • 제12권4호
  • /
  • Pages.376-379
  • /
  • 1991
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  • 0253-2964(pISSN)
  • /
  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Peptide Synthesis with Polymer Bound Active Ester. Ⅱ. Synthesis of Pyrazolone Resin and Its Application in Acylation Reaction

  • Jong-Bum Kim (Department of Chemical Technology, Seoul National University) ;
  • Yoon-Sik Lee (Department of Chemical Technology, Seoul National University)
  • 발행 : 1991.08.20
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초록

Pyrazolone group containing resin was tested as an acyl carrier in solid phase peptide synthesis. Several kinds of dipeptide derivatives were prepared by aminolysis reactions of Boc-amino acid-pyrazolone resin active ester with various carboxyl protected amino acid derivatives. It was found that the rates of aminolysis reactions were largely dependent on the bulkiness of the amino acid side chains, the carboxyl protecting groups, and the swelling property of the resin. All the dipeptide derivatives were obtained in high yield in 20-30 minutes, and the pyrazolone resin could be reused repeatedly in peptide synthesis without any change of its reactivity.

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참고문헌

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피인용 문헌

  1. Carbonyl Stress Reduction in Peritoneal Dialysis Fluid: Development of a Novel High-Affinity Adsorption Bead vol.27, pp.3, 1991, https://doi.org/10.1177/089686080702700316