Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Development of New Protecting Groups for Guanine Residue in Oligodeoxyribonucleotide Synthesis

  • Byung Jo Moon (Department of Biochemistry, College of Natural Sciences, Kyungpook National University) ;
  • Kyung Lan Huh (Department of Chemistry, Seoul National University)
  • Published : 1991.04.20
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Abstract

Attempts were made to develop new protecting groups for 1,6-lactam function of 2-N-acyl guanine in oligodeoxyribonucleotide synthesis. Several acyl groups, aryl groups, and carbamoyl groups were tested. Dimethylcarbamoyl and phenylacetyl groups are shown to be a good combination for guanine residue. 6-O-Di-methylcarbamoyl-2-N-pheylacetyl-2'-deoxy guanosine have been successfully used in the synthesis of d[AAGCTT], which is Hind Ⅲ recognition sequence.

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References

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Cited by

  1. ChemInform Abstract: Development of New Protecting Groups for Guanine Residue in Oligodeoxyribonucleotide Synthesis. vol.22, pp.39, 1991, https://doi.org/10.1002/chin.199139235
  2. Synthesis of the Oligoribonucleotides Incorporating 8-Oxo-Guanosine and Evaluation of their Base Pairing Properties vol.32, pp.3, 2013, https://doi.org/10.1080/15257770.2013.767461