A comparative study of the major component of the protein secretion machinery, secY, in gram positive bacillus subtilis and gram negative escherichia coli.

그람 양성균인 Bacillus subtilis와 그람 음성균인 escherichia coli에서 protein secretion에 중요 역할을 하는 secY에 대한 비교 연구

A phylogenetic comparison of homologous protein can often supplement genetic and biochemical analysis by revealing conserved structures that are critical for function(Waugh et al., 1989). I therefore isolated a secY homologue from B. subtilis, a gram positive bacterium evolutionary distant from E. coli. The comparison and interplay between these two bacterial systems should contribute greatly to our understanding of the functions and interactions within systems evolved for protein translocation in both prokaryotic and eukaryotic organisms.