Toxicological Research

  • 제7권1호
  • /
  • Pages.93-112
  • /
  • 1991
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

STUDIES OF VARIOUS FACTORS ON INDUCTION OF EXPERMIMENTAL HEPATOCARCINOGENESIS IN SPRAUGE-DAWLEY RATS

  • Jeong, Ja-Young (College of Veterinary Medicine Seoul National University) ;
  • Kim, Hyoung-Chin (College of Veterinary Medicine Seoul National University) ;
  • Lee, Yong-Soon (College of Veterinary Medicine Seoul National University)
  • 발행 : 1991.06.01
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초록

This study was carried out to investigate the various factors on induction of experimental hepatocarcinogenesis in Sprauge-Dawley rats. The experimental animals were divided into three Experiment. Experiment I, II and III were began rats with initial age of 6, 16 and 55 weeks, respectively. All Experiment were injected intrapertioneal with diethylnitrosamine (DENA` 200 mg/kg) as an intiator and group 3, 4 of Experiment I, II and III were fed on diet containing 0.02% 2-acetylaminofluorene (2-AFF) as a promoter for 6 weeks. Three weeks after two-thirds partial hepatectomy was performed in group 2, 4 of Experiment I & II and group 3 of Experiment III.

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