Inhibitory Effects of Glipizide on Cromakalim-induced Vasorelaxative and Hypotensive Action in the Rats

Rat에서 Cromakalim에 의해 유발된 혈관이완 및 혈압강하작용에 대한 Glipizide의 억제작용

The inhibitory effects of glipizide on cromakalim-induced relaxation of aortae and hypotension in the anesthetized rats was examined. In rat thoracic aortic rings pre-contracted with norepinephrine, cromakalim produced a relaxation sustainedly. This relaxation was completely inhibited by pre- or post-treatment of glipizide. In the anesthetized rat, cromakalim produced a rapid and sustained fall in the arterial blood pressure. This hypotensive action of cromakalim was abolished by pre- or post-treatment of glipizide. It is suggested that glipizide is the potent inhibitor of cromakalim, $K^{+}$ channel opener, in the rats.