Archives of Pharmacal Research
- Volume 14 Issue 3
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- Pages.266-270
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- 1991
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis of C-(2-Furyl)-N-(4-nitrophenyl)methanohydrazonyl Bromide. Reactions with Nucleophiles and Active Methylene Compounds
- Hassaneen, Hamdi M. (Department of Chemistry, Faculty of Science, University of Cairo) ;
- Shawali, Ahmad S. (Department of Chemistry, Faculty of Science, University of Cairo) ;
- Elwan, Nehal M. (Department of Chemistry, Faculty of Science, University of Cairo) ;
- Ibrahim, Al Hossien A. (Department of Chemistry, Faculty of Science, University of Cairo)
- Published : 1991.09.01
Abstract
Synthesis of C-(2-furyl)-N-(4-nitrophenyl)methanohydrazonyl bromide 2 is described. Treatment of 2 with uncleophiles affords the corresponding substitution products 3-7. Also, compound 2 reacts with selenocyanate anion and thiocyanate anion and give the corresponding selenadiazoline and thiadiazoline 8 and 9, respectively. Moreover, reaction of 2 with enolates of various active methylene compounds afforded the pyrazole derivatives 17-20.