Archives of Pharmacal Research
- 제14권3호
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- Pages.242-248
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- 1991
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Antihypertensive and Cardiovascular Effects of the New Calcium Antagonist YH334
- Lee, Jong-Wook (Yuhan Research Center, Yuhan Corporation) ;
- Han, Byung-Hee (Yuhan Research Center, Yuhan Corporation) ;
- Lee, Jeong-Won (Yuhan Research Center, Yuhan Corporation) ;
- Seok, Ji-Hee (Yuhan Research Center, Yuhan Corporation) ;
- Kim, Su-Chang (Yuhan Research Center, Yuhan Corporation) ;
- Hong, You-Hwa (Yuhan Research Center, Yuhan Corporation) ;
- HongSuh, Jung-Jin (Yuhan Research Center, Yuhan Corporation) ;
- Hong, Soon-Uk (Yuhan Research Center, Yuhan Corporation)
- 발행 : 1991.09.01
초록
Antihypertensive effect of YH 334 was examined in various experimental hypertension rat models and the systemic and regional hymohynamic profiles of the compound were investigated in conscious spontaneously hypertensive rats (SHR). The antiypertensive potensive potency of YH 334 is found to be more than 10 times stronger than that of nitrendipine in the all hypertensive models. The effective doses to lower the initial blood pressure by 20%
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