Effect of Ginsenosides of Red Ginseng on Lipolytic Action of Toxohormone-L from Cancerous Ascites Fluid

암독소 호르몬-L이 유발하는 체지방 분해작용에 고려인삼의 각 진세노사이드 성분이 미치는 영향

  • 이성동 (고려대학교 병설 보건전문대학 식품영양과) ;
  • 황우익 (고려대학교 의과대학 생화학교실)
  • Published : 1991.08.01

Abstract

This study was devised to obserL'e the inhibitory effects of 7 kinds of ginsenosides on a lipolytic action of Toxohormone-L. The ginsenosides used in this experiment were -Rbl, -Rbl, - Rc, - Re, - Rgl, and - Rg2 prepared from Korean red ginseng. Toxohormene-L was partially purified by centrifigation from the ascites fluids of Sarcoma-180 bearing mice. In vitro test showed that the inhibitory effect of - Rb2 on the lipolysis by Toxohormone-L was highest percent among other treatments at concentration of 100 $\mu\textrm{g}$/ml and 500 $\mu\textrm{g}$/ml of reaction mixture. And total inhibitory activity (units) of - Rb2 was also highest among other treatments at the same concentration. However, in vivo test, body weight gain of Sarcoma-180 bearing mice decreased significantly by administration of - Rg2 compared to those of the control or other ginsenosides treated groups.

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