한국임상약학회지 (Korean Journal of Clinical Pharmacy)
- 제1권1호
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- Pages.1-7
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- 1991
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- 1226-6051(pISSN)
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- 2508-786X(eISSN)
Methotrexate의 임상약동력학적 고찰
Review on the Clinical Pharmacokinetics of Methotrexate
초록
Folates are involved in a variety of important biosynthesis by way of donating one carbon unit. Since folate metabolism was well understood a number of antifol have been developed. Among these antifols, aminopterin was first used in the treatment of childhood leukemia. However due to its toxicity and purity problems. it was immediately replaced by another antifols. methotrexate (MTX). MTX is shown to be active against various malignancies including leukemia breast cancer, osteogenic sarcoma, and head and neck cancer. Clinically, MTX therapy is divided into 3 categories. depeding on the dose administered; low-dose is defined as doses <
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