Journal of Pharmaceutical Investigation
- Volume 21 Issue 4
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- Pages.247-251
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- 1991
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Effect of Cimetidine and Antacid on Pharmacokinetics of Minocycline
시메티딘 및 제산제가 미노싸이클린의 약물동태에 미치는 영향
- Jung, Eui-Cha (College of Pharmacy, Chung Ang University) ;
- Park, Gee-Bae (College of Pharmacy, Chung Ang University) ;
- Shin, Hwa-Woo (College of Pharmacy, Won Kwang University) ;
- Choi, Young-Wook (College of Pharmacy, Chung Ang University) ;
- Lee, Kwang-Pyo (College of Pharmacy, Chung Ang University)
- Published : 1991.12.20
Abstract
Effects of aluminum magnesium hydroxide (A) and cimetidine (C) on the pharmacokinetics of minocycline (M) were investigated in female rats. Blood samples were collected at various time intervals until 36 hrs following oral dosing of drugs. Plasma minocycline concentrations were determined by HPLC. Control group (M),