Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Effect of Ephedrae Herba on the Immune Response in Mice

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  • Kim, Tae-Hee (College of Pharmacy, Sookmyung Women's University) ;
  • Yang, Ki-Sook (Seoul Metropolitan Government Institute of Health and Environment) ;
  • Hwang, Eun-Zin (Seoul Metropolitan Government Institute of Health and Environment) ;
  • Park, Sung-Bae (Seoul Metropolitan Government Institute of Health and Environment)
  • 김태희 (숙명여자대학교 약학대학) ;
  • 양기숙 (서울시 보건환경연구원) ;
  • 황은진 (서울시 보건환경연구원) ;
  • 박성배 (서울시 보건환경연구원)
  • Published : 1991.09.30
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Abstract

The effects of Ephedrae herba on cellular and humoral immune responses were investigated in mice. Group A and B of mice received intraperitoneal injection of methanol extracts, ether fraction(E), petroleum ether fraction(PE), ethyl acetate fraction(EA) and water fraction(W) for 5 days or 10 days before sensitization. The other group received i.p. injection of ephedrine (Ep) or pseudoephedrine $({\psi}\;Ep)$ for 1 day prior to sensitization. The change of body and spleen weights showed a tendency of decreasing but that of thymus showed increasing. Ear swelling was maximum at 48 hours after challenge and was significantly decreased in the groups treated with EA, W, Ep, and ${\psi}\;Ep$. HA titer was enhanced in EA, W and EP treated groups, HE titer being significantly decreased.

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