Archives of Pharmacal Research
- Volume 14 Issue 4
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- Pages.346-351
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- 1991
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
The Metabolism of Xylazine in Rats
- ParkChoo, Hea-Young (School of Pharmacy, Ewha Womans University) ;
- Choi, Sun-Ok (School of Pharmacy, Ewha Womans University)
- Published : 1991.12.01
Abstract
The biotransformation of xylazine, a widly used animal tranquilizer, was investigated in rats. After administration of xylazine, the existence of 2,6-dimethylphenyl-isothiocyanate, 2,6-dimenthyl-4-hydroxy-aniline and p-hydroxy-xylazine in urine was confirmed by the comparison with chemically prepared standards in GC/MS. The main metabolite, p-hydroxy xylazine was excreted as conjugated form.
Keywords
- Xylazine metabolism;
- 2,6-dimenthylphenylisothiocyanate, 2,6-dimethyl-4-hydroxy-aniline;
- 4-hydroxy-xylazine