Archives of Pharmacal Research
- Volume 14 Issue 1
- /
- Pages.78-80
- /
- 1991
- /
- 0253-6269(pISSN)
- /
- 1976-3786(eISSN)
Synthesis and Anti-Inflammatory and Analgesic Activities of 2,4-Di-n-butyl-3,5-diarylimino-1,2,4-thiadiazolidines
- Pandeya, S.N. (Department of Pharmaceutics, Institute of Technology) ;
- Naik, P.R. (Banaras Hindu University) ;
- Singh, S. (Banaras Hindu University) ;
- Singh, P.N. (Banaras Hindu University)
- Published : 1991.03.01
Abstract
Ten 1,2,4-thiadiazolidines were synthesized and screened for their anti-inflammatory and analgesic activities. Butyl isothiocyanate was used as a starting material. Several compounds showed significant anti-inflammatory and analgesic activities. The unsubstituted and o-methyl, p-acetoxy and o-chloro substituted compounds were found to be more potent anti-inflammatory and analgesic agents than the other compounds.