Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

A STUDY ON POTENTIAL PROTECTIVE ACTIVITIES OF GLUTATHIONE AND CHLORPROMAZINE AGAINST OXYGEN TOXICITY

산소중독에 대한 Glutathione과 Chlorpromazine의 보호효과에 관한 실험적 연구

  • Lim, Hyun-Sul (Department of Preventive Medicine, College of Medicine, Dong-guk University, Dong-guk University Pohang Hospital) ;
  • Yun, Dork-Ro (Department of Preventive Medicine, College of Medicine, Seoul National University)
  • 임현술 (동국대학교 의과대학 예방의학교실) ;
  • 윤덕로 (서울대학교 의과대학 예방의학교실)
  • Published : 1990.12.01
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Abstract

Effective measure to prevent oxygen toxicity is greatly required as there increase chances to be exposed to high oxygen pressure, for example, space travel, deep sea diving and hyperbaric oxygen therapy. In the present study, in an attempt to evaluate glutathione and chlorpromazine as protective agents against oxygen toxicity, effects of the agents were tested on various toxicities (death rate, convulsion rate, time to convulsion, increase in weight of lung and brain and pathological changes in the organs) observed in rats exposed to 5 Absolute Atmosphere (ATA) of 100% oxygen for 120 minute. Glutathione reduced mortality rate and convulsion rate and also markedly suppressed the increase in lung and brain weight. The pathological changes observed in these organs were ameliorated by administration of glutathione. Chlorpromazine also reduced mortality rate but its effects appeared to be limited mainly to pulmonary toxicities. Thus glutathione seems to be more effective than chlorpromazine as a protective agent. The results obtained may support that oxygen toxicity is mediated by oxygen free radicals.

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