The Korean Journal of Nuclear Medicine (대한핵의학회지)

The Korean Society of Nuclear Medicine (대한핵의학회)
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A Comparative Pharmacokinetic and Biodistributional Study of $^{131}I$ OIH and $^{99m}Tc-MAG_3$

$^{131}I$ OIH와 $^{99m}Tc-MAG_3$의 약물동력학 및 체내 분포에 관한 비교 연구

  • Jeong, Jae-Min (Department of Nuclear Medicine, Seoul National University Hospital) ;
  • Yeom, Mi-Kyoung (Department of Nuclear Medicine, Seoul National University Hospital) ;
  • Kim, Mun-Hye (Department of Nuclear Medicine, Seoul National University Hospital) ;
  • Park, Kyung-Ho (Department of Pharmacy, Seoul National University Hospital) ;
  • Song, Sae-Heum (Department of Pharmacy, Seoul National University Hospital) ;
  • Lee, Bum-Woo (Department of Internal Medicine, College of Medicine, Seoul National University) ;
  • Lee, Dong-Soo (Department of Internal Medicine, College of Medicine, Seoul National University) ;
  • Chung, June-Key (Department of Internal Medicine, College of Medicine, Seoul National University) ;
  • Lee, Myung-Chul (Department of Internal Medicine, College of Medicine, Seoul National University) ;
  • Cho, Bo-Youn (Department of Internal Medicine, College of Medicine, Seoul National University) ;
  • Koh, Chang-Soon (Department of Internal Medicine, College of Medicine, Seoul National University)
  • 정재민 (서울대병원 핵의학과) ;
  • 염미경 (서울대병원 핵의학과) ;
  • 김문혜 (서울대병원 핵의학과) ;
  • 박경호 (서울대병원 약제부) ;
  • 송세흠 (서울대병원 약제부) ;
  • 이범우 (서울대학교 의과대학 내과학교실) ;
  • 이동수 (서울대학교 의과대학 내과학교실) ;
  • 정준기 (서울대학교 의과대학 내과학교실) ;
  • 이명철 (서울대학교 의과대학 내과학교실) ;
  • 조보연 (서울대학교 의과대학 내과학교실) ;
  • 고창순 (서울대학교 의과대학 내과학교실)
  • Published : 1990.04.25
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Abstract

$^{99m}Tc-MAG_3$ was synthesized, and biodistribution and blood clearance rate were compared with those of $^{131}I-OIH$ in mice and rats respectively. Finally renal image was obtained from a normal male volunteer before and after prescription of probenecid. The results obtained were as follows: 1) The uptake of $^{99m}Tc-MAG_3$ by kindey was higher than that of $^{131}I-OIH$ in mice 10 mins after injection (n=6, p<0.05), but slightly lower uptakes were found in all organs (kindney, blood, stomach, intestinge and liver) 2 hrs after injection. 2) For $^{99m}Tc-MAG_3$ $4\frac{1}{2}\;\alpha=2.4{\pm}0.0\;min,\;t\frac{1}{2}\;\beta=44.3{\pm}7.4\;min$, and blood clearance=$3.4{\pm}0.5ml/min$, and for $^{131}I-OIH\;t\frac{1}{2}\;\alpha=1.8{\pm}0.2\;min,\;\beta=69.1{\pm}9.5\;min$, and blood clearance=$1.3{\pm}0.1\;min$ were found in rats. 3) From the renogram of normal male volunteer, we could find that tmax=130 sec and $t\frac{1}{2}=430\;sec$ before probenecid prescription, and $tmax=150\sim170$ sec and $t\frac{1}{2}=810\sim1,170$ sec after probenecid prescriprion. From these results we concluded that $^{99m}Tc-MAG_3$ can be used instead of $^{131}I-OIH$ for obtaining renal image.

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