The Korean Journal of Nuclear Medicine (대한핵의학회지)
- Volume 24 Issue 1
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- Pages.29-36
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- 1990
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- 1225-6714(pISSN)
Radioimmunoscintigraphy Using IMACIS-1 in Gastrointestinal Cancer
IMACIS-1을 이용한 위장관 종양의 방사면역신티그램
- Sohn, Hyung-Sun (Department of Radiology, Catholic University Medical College) ;
- Kim, Choon-Yul (Department of Radiology, Catholic University Medical College) ;
- Bahk, Yong-Whee (Department of Radiology, Catholic University Medical College)
- Published : 1990.04.25
Abstract
Most of the diagnostic methods currently used for the detection of neoplastic masses provide indirect evidence. To obtain greater specificity in the interpretation of neoplasias by in vivo methods, the immunological approach appears to be most promising. Two problems that interfered with progress in this field were the lack of tumor specific antigen and the lack of well-defined and reproducible antibodies. To improve the sensitivity and specificity of radioimmunoscintigraphy as a technique for tumor localization, the use of monoclonal antibodies, fragments of antibodies and single photon emission computerized tomography (SPECT) are reasonable. The obvious advantages of monoclonal antibodies are their homogeneity, their specificity for the immunizing antigen and the reaction with a single determinant-thus no large immunecomplexes with antigen are formed. Monoclonal antibody technique has recently provided an opportunity to reevaluate the role of nuclear medicine for the diagnosis of malignant diseases by using the immunological approach. Out first results by means of radioimmunoscintigraphy of CEA and CA 19-9 producing tumors using a cocktail of fragments F
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