Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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New Aminothiazolyl Cephalosporins. Synthesis and Biological Evaluation of 7-[Alkoxyiminomethyl(2-aminothiazol-4-yl)acetamido]ceph-3-em-4-carboxylic Acids

  • Koh, Hun-Yeong (Chemistry Division, Korea Institute of Science and Technology) ;
  • Kang, Han-Young (Chemistry Division, Korea Institute of Science and Technology) ;
  • Choi, Kyung-Il (Chemistry Division, Korea Institute of Science and Technology) ;
  • Chang, Moon-Ho (Chemistry Division, Korea Institute of Science and Technology)
  • Published : 1990.12.20
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Abstract

New aminothiazolyl cephalosporins with alkoxyiminomethyl(2-aminothiazol-4-yl)acetyl substituents at 7-position of cephems were synthesized starting from (2-aminothiazol-4-yl)acetate via one carbon homologation followed by acylation with 7-aminoceph-3-em-4-carboxylic acid derivatives. These new aminothiazolyl cephalosporins exhibit promising in vitro activities against various strains including Gram positive bacteria.

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  1. ChemInform Abstract: New Aminothiazolyl Cephalosporins. Synthesis and Biological Evaluation of 7-(Alkoxyiminomethyl(2-aminothiazol-4-yl)acetamido)ceph-3-em-4- carboxylic Acids. vol.22, pp.28, 1990, https://doi.org/10.1002/chin.199128244