Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Structure and Activity of Quinolone Antibacterial Agents. 1. 7-Substituted 1-Ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acids

  • Shin, Youn-Ho (Korea Research Institute of Chemical Technology) ;
  • Ryu, Eung K. (Korea Research Institute of Chemical Technology) ;
  • Kang, Young-Kee (Department of Chemistry, Chungbuk National University)
  • Published : 1990.10.20
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Abstract

To find out a correlation between antibacterial activity and physical properties of 7-substituted 1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, dipole moments, charge distributions, and hydrophobicities were calculated. The atomic charges and the dipole moments to not give any correlations with inhibition of DNA gyrase, but the calculated hydration free energies show some correlations.

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