Synthesis and Biological Activities of the Alternating Copolymers Containing Cyclic Ether Rings along with Carboxyl or Hydroxyl Groups on Their Backbones

  • Man Jung Han (Department of Applied Chemistry, Ajou University) ;
  • Shin Duk Kang (Department of Applied Chemistry, Ajou University) ;
  • Won Young Lee (Department of Microbiology, School of Medicine, Yonsei University)
  • Published : 1990.04.20


The alternating copolymers of dihydropyran(DP)-maleic anhydride(MA), dihydrofuran(DF)-MA and DF-vinylene carbonate(VC) were prepared by free radical copolymerization of DP or DF with MA or VC. The reactivity ratios for poly(DF-VC) were found to be less than unity (0.05, 0.04) and its alternating sequences were obtained by feeding an equimolar amount of the comonomers at the onset of copolymerizations. The copolymers were hydrolyzed to give poly(TP-CE), poly(TF-CE) and poly(TF-HE), whose cytotoxicities against normal and tumor cells (3LL, B16) were measured in vitro.