한국환경성돌연변이발암원학회지 (Environmental Mutagens and Carcinogens)
- 제10권1호
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- Pages.1-10
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- 1990
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- 1225-6307(pISSN)
적응반응 관련 DNA 회복유전자의 발현조절에 관한 연구
Regulatory Expression of DNA Repair Genes Involved in Adaptive Response
초록
The regulation of DNA repair genes expression was investigated using fused genes, in which the promoter of repair genes was hybridized with the lacZ structural gene. The activities of beta-galactosidase expressed from the fused gense were highly increased when the host cells were exposed to methylating agents, such as methyl methansulfonate (MMS), N-methyl-N'-nitro-nitrosoguanidine (MNNG) and methyl nitrosourea (MNU). On the other hand, the enzyme activities from the fused genes were not induced when the cells were treated with ethylating or nonalkylating agents, such as ethyl methansulfonate (EMS), 4-nitroquinoline-1-oxide (4NQO), Bleomycin, and Benzo(a)pyrene (BP).
키워드