한국동물학회지 (The Korean Journal of Zoology)
- 제33권4호
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- Pages.493-498
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- 1990
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- 0440-2510(pISSN)
6-Aminonicotinamide가 토끼혈청내 효소 및 대사물질에 미치는 영향
Effect of 6-Aminonicotinamide on the Levels of Some Metabolites and Related Enzymes in Rabbit Serum
- Park, In-Koo (Department of Agrobiology, Dong Guk University) ;
- Lee, Chul-Seung (Department of Agrobiology, Dong Guk University) ;
- Lee, Seung-Hoon (Department of Agrobiology, Dong Guk University) ;
- Song, Yoon-Kyung (Department of Agrobiology, Dong Guk University) ;
- Shin, Sook (Department of Biology, Mokpo National University)
- 발행 : 1990.10.01
초록
Antimetabolited인 6-aminonicotinamide(6-AN)가 토끼의 혈청내 효소 및 대사 물질에 미치는 영향에 관하여 연구하였다. 복강투여시 (l5mg/kg의 체중) 포도당과 콜레스테놀농도는 현저이 증가하였으나 알부민고 총단백질량은 크게 변하지 않았다. Creatine phophokinase,glutamic oxaloacetate transaminase,glutamic pyruvate transaminase 및 alctate dehydrogensenase활성은 매우 증가하였으며 alkaline phosphatase와 Ca, P, Na, K, Cl 및 Co등의 수준은 영향을 받지 않았다.
The effects of an antimetabolite, 6-aminonicotinamide (6-AN) on the levels of enzymes and metabolites in rabbit serum were investigated. The intraperitoneal administration of 6-AN (multiple doses of l5mg/kg body weight) gave tise to a remarkable increase in glucose and cholesterol levels but did not exert any appreciable influence on the concentration of albumin and total protein. Alkaline phosphatase activity was significantly reduced by administration of 6-AN, whereas creatine phophokinase, serum glutamic oxaloacetate transaminase and serum glutamic pyruvate transaminase activities were matkedly enhanced. Nevettheless, the levels of Ca, P, Na, K, Cl and Co were not affeded to any extent by 6-AN.
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