Archives of Pharmacal Research
- Volume 13 Issue 4
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- Pages.310-313
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- 1990
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis of 4-(2, 4 dioxo-5-pyrimidyl)-1, 4-dihydropyridine Derivatives
- Suh, Jung-Jin (Yuhan Research Center) ;
- Hong, You-Hwa (Yuhan Research Center) ;
- Bae, Myn (Yuhan Research Center)
- Published : 1990.12.01
Abstract
Hantzsch synthesis of 5-formyluracil (1) methyl acetoacetate (2) and methyl 3-aminocrotonate (3) gave 2, 6-dimethyl-4-(2, 4-dioxo-5-pyrimidy)-1, 4-dihydropyridine-3, 5-dicarboxylic acid dimethylester (4a) in 54.6 yield. As the same procedure, 1, 3-dimethyl-5-formyl-uracil (6) gave 2, 6-dimethyl-4-(1, 3-dimethyl-2, 4-dioxo-5-pyrimidyl)-1, 4-dihydropyridine-3, 5-dicarboxylic acid dimethyl easter (7a) IN 52.2% yield. 4a was methylated to afford 7a also in 52% yield.
Keywords
- 1,4-Dihydropyridines;
- nifedipine;
- Hantzsck synthesis;
- 4-(2,4-dioxo-5-pyrimidyl)-1;
- 4-dihydropyridine