Effects of Lignans on Hepatic Drug-Methabolizing Enzymes

  • Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University) ;
  • Woo, Won-Sick (Natural Products Research Institute, Seoul National University) ;
  • Lee, Jung-Yun (Department of Home Economics, Korea University) ;
  • Han, Yong-Bong (Department of Home Economics, Korea University)
  • Published : 1990.09.01

Abstract

The effects of lignans, related to macelignan, on hepatic microsomal drug-metabolizing enzyme (DME) activity were evaluated to elucidate the structure-activity relationship in mice and rats. The compounds carrying the methylenedioxyphenyl nucleus were found to be the msot potent among compounds tested; which not only produced a marked inhibition of DME with a single dose but a significant induction with repeated treatments. Lack of the methylenedioxy group caused marked decrease in the activity, implying that a methylenedioxy group is essential and of major importance eliciting DME modifying activity.

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