Archives of Pharmacal Research
- Volume 13 Issue 2
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- Pages.132-135
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- 1990
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Antioxidant Activity Resveratrol Closely Correlates with Its Monoamine oxidase-A Inhibitory Activity
- Han, Yong-Nam (Natural Products Research Institute, Seoul National University) ;
- Ryu, Shi-Yong (Natural Products Research Institute, Seoul National University) ;
- Han, Byng-Hoon (Natural Products Research Institute, Seoul National University)
- Published : 1990.06.01
Abstract
Polyhydroxystilbenes including resveratrol were reported to competitively inhibit monoamine oxidase-A-without structural relation with substrates and cynthetic inhibitors for the enzyme. We attempt to explore a plausible mechanism for their inhibitory activity on MAO-A. All the polyhydroxystilbenes tested showed the antioxidant activity on liver homogenate. Furthermore, the antioxidant activity turned out to closely correlate with the MAO-A inhibitory activity.